In 2022, the advocacy group Facing Fentanyl designated Aug. 21 “National Fentanyl Prevention and Awareness Day,” to honor the people who have died from fentanyl and to increase public awareness of its toll. Fentanyl use can result in death even with one dose, especially if a person accidentally takes it incorrectly. Research has found that pregnant women with untreated addiction may be less likely to get regular prenatal care. This can raise their risk of serious or even deadly pregnancy complications. Repeated fentanyl use can lead to dependence, which means that the person’s body gets used to the presence of the drug.
Fentanyl Overdose
Manufacturers use chemicals to make a substance with the same chemical structure as poppies to make fentanyl in a lab. Call an ambulance right away if you suspect you or someone you’re with may have taken an overdose. Drug enforcers theorize that dyes may help drug traffickers avoid detection with the drugs. They speculate that it may also be a way to tempt teens and young adults to take them. The claim that some of the colors have a stronger effect than others is a myth. Read on to learn about the methods, benefits, risks and implications of using or misusing fentanyl.
For more recent provisional data, please see Provisional Drug Overdose Death Counts from NCHS. Timely data related to unintentional and undetermined intent drug overdose deaths by participating jurisdiction is also available from the CDC’s State Unintentional Drug Overdose Reporting System (SUDORS). Similar data related to nonfatal drug overdoses are reported through CDC’s Drug Overdose Surveillance and Epidemiology (DOSE) system. This webpage is regularly updated to display the most recent final drug overdose death data published annually by NCHS. NCHS systems receive and analyze data from death certificates, including cause-of-death information reported by state and local medical examiners and coroners. Because drug overdose deaths often require lengthy investigations, data are updated as new information is received.
Therapeutic Effects

The drug also causes a shorter-lived high than other opioids, meaning users must take the drug more frequently to avoid withdrawal. “Street drugs have gotten a lot more variable since the start of the pandemic. Now you have mom and pop shops making street drugs – that creates disincentives for stability and control,” Dasgupta said.
Understanding The Fentanyl Crisis
Despite the lifesaving track records of these medications, their availability is limited by restrictions on where and how they can be used and inadequate numbers of prescribers. Overdose deaths usually lead to investigation by law enforcement, which is bad for business and can often result in the dealer’s arrest. However, the drug is so profitable that it’s worth the risk.
It can be hard to function without the drug in your system. Most people need help from a health professional or program to successfully quit. One line is a positive result and means there is fentanyl in your drug supply. After a fentanyl treatment, you may have side effects that hinder your thinking and reactions or cause dizziness or drowsiness.

Q: How Dangerous Is Fentanyl?
If you unknowingly take fentanyl in another drug, you may overdose since fentanyl is so potent. Withdrawal symptoms typically start within 12 hours after your last dose of the drug. The first 3 days are the hardest, with the most severe symptoms. But these tips can reduce some of that risk and lower your chances of overdose, infection, or other problem.
How To Use Fentanyl Safely
Keep track of how much fentanyl is left so you will know if any is missing. Store fentanyl at room temperature and away from excess heat and moisture (not in the bathroom). This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information. The information contained on this website is not intended to be a substitute for, or to be relied upon as, medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Chronic Pain
A growing number of experts believe that deadly street fentanyl is suddenly drying up in many parts of the country. It is more expensive, and it’s being sold in a form that’s weaker, less potent. Some researchers believe these changes are driving a national drop in drug deaths. We’re going to talk this through with NPR addiction correspondent Brian Mann. The United States is in the middle of a devastating opioid epidemic, and its deadliest driver is fentanyl. This synthetic opioid, far more potent than heroin, is fueling a tragic and alarming surge in overdose deaths.

After you’ve taken an opioid like fentanyl for a long time, your brain gets used to the drug. This means your tolerance goes up and it takes more of it to get the same effect. You also have trouble feeling pleasure from anything besides the drug. This more recent version of fentanyl comes in bright colors.
What Should I Know About Storage And Disposal Of This Medication?
- In 2022, the DEA seized more than 50 million street pills laced with fentanyl — more than twice as many in 2021.
- Taking too many opioids at one time can cause a person to stop breathing and die.
- Watch a video on How to use fentanyl test strips from Prevent Overdose-Rhode Island.
- The liquid form is often dropped on paper or small candy, leading to the potential for tragic deaths among children.
- By 2021, fentanyl was involved in the vast majority of overdose deaths, according to the National Center for Health Statistics.
Fentanyl, synthetic narcotic analgesic drug, the most potent narcotic in clinical use (50 to 100 times more potent than morphine). The citrate salt, fentanyl citrate, is administered by injection, either intramuscularly or intravenously, sometimes in combination with a potent tranquilizer. The medication will reverse the effects of fentanyl and block future effects.
FIND TREATMENT:
Its strong potency means it can be used in operating rooms, to control pain after surgery and to alleviate pain for people with advanced cancer. But its effectiveness at relieving pain and increasing pleasure also have made it a popular street drug with dangerous risks of addiction, overdose and death. Call your doctor if you experience more than four episodes of breakthrough pain per day or if you have new pain or an increased sensitivity to pain during your treatment with fentanyl. Your doctor may need to adjust the dose of your other pain medication(s) to better control your pain. Fentanyl can be illegally mixed into other substances, including heroin, cocaine, ecstasy, and methamphetamine (NIDA, 2021). This combination can result in an individual consuming a much stronger substance than they are used to, resulting in overdose and possibly death.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. When it is intentionally misused, fentanyl often shows up as a powder, spiked on blotter paper or is mixed with or substituted for heroin and other street drugs. Fentanyl is an extremely dangerous substance, and has been responsible for many fatal overdoses in the past several years. Read on to learn more about it and help protect your loved one. The use of fentanyl citrate injection with CYP3A4 inducers or stopping the CYP3A4 inhibitor will require close and repetitive monitoring of the patient.