Your doctor may need to adjust the dose of your other pain medication(s) to better control your pain. Fentanyl and similar compounds like carfentanil are powerful synthetic opioids 50 to 100 times more potent than morphine. Naloxone — also known by the brand names such as Narcan and Kloxxado — is a prescription medication that reverses an opioid overdose. While it works quickly, naloxone is a temporary solution that works for 30 to 90 minutes. It’s available both for those who have been prescribed fentanyl and those who are misusing fentanyl.
Fentanyl can continue to be effective after removing the patch, as the skin has already absorbed the drug. However, the amount of time it remains effective depends on the individual. As with other opioid drugs, fentanyl binds to the receptors in the brain that affect pain and emotion. This causes feelings of well-being (euphoria) and relaxation and relieves pain. This campaign also shows the difference between counterfeit pills and real pills.

Fentanyl May Interact With Other Medications
Over the past decade, fentanyl that is made and distributed illegally has become increasingly common in the illegal drug supply and has contributed to a surge in drug overdose deaths. Typically, a fentanyl overdose manifests as an extrapolation of its pharmacological side effects. Although the clinical scenarios may vary among patients, one of the main concerns is the level of expression of OIRD. In such cases, oxygen administration and respiratory assistance are a priority. An opioid drug antagonist such as naloxone can help to correct OIRD symptoms. Thus, the therapeutic approach should continue until a normal respiratory rate coincides with appropriate oxygen saturation levels.
What Are The Possible Effects Of Fentanyl?

These sounded like sophisticated operations, offering discounts on bulk purchases and even trying to upsell the investigators to carfentanil, an even more powerful opioid. An 11-month-old girl swallowed a blue tablet she found while crawling around a new apartment. Additional testing was positive for fentanyl, methamphetamine, acetaminophen, and tramadol (from Joynt & Wand, 2021). If a person has a susceptibility to addiction, then it is a situation where the person is more likely to develop a substance use disorder. The physical and mental effects of fentanyl vary depending on how it is used.
Why Is It So Dangerous?
Naloxone comes in two forms — injectable and a nasal spray. The nasal spray version is the only one that will be available for people to get over the counter. When you are ready to administer the nasal spray, gently tilt the person’s head back and provide support with your hand under their neck.
Stop Overdose

You may use the second lozenge (Actiq) 15 minutes after you finish the first lozenge, or use the second tablet (Fentora) 30 minutes after you started using the first tablet. Talk to your doctor about how well the medication is working and whether you are experiencing any side effects so that your doctor can decide whether your dose should be adjusted. Do not take more of it or take it more often than prescribed by your doctor. Fentanyl is a synthetic opioid that can be prescribed by doctors for pain management (National Institute on Drug Abuse NIDA, 2021). It is also increasingly found mixed into street drugs (Drug Enforcement Administration DEA, 2024). Understanding the dangers of fentanyl is crucial, especially for individuals who might unknowingly consume it or use it without a doctor’s prescription.
- Portman and a bipartisan group of senators have actually introduced legislation to require the Postal Service to collect this electronic data.
- The staff started, quite literally, by Googling “fentanyl for sale,” they said.
- In a medical setting, people take prescribed fentanyl for severe or chronic pain.
- If you stop taking your other pain medication(s) you will need to stop using fentanyl.
- For instance, some can interfere with how well a drug works, while others can cause increased side effects.
Overdose Prevention

Attempting to obtain fentanyl without a prescription can have serious consequences. Fentanyl is approximately 50 to 100 times more potent than morphine and even a small amount can be lethal if misused. In recent years, there has been a surge in overdoses and deaths related to illicitly manufactured fentanyl. Fentanyl should only be prescribed by doctors who are experienced in treating pain in cancer patients. Fentanyl may cause serious breathing problems or death if it is used by people who are not being treated with other narcotic medications or who are not tolerant to narcotic medications. “In health care, we dose fentanyl in micrograms,” explains Amanda N. Donald, MD, an addiction medicine physician at Northwestern Medicine.
Over the last decade, the conversation of the opioid epidemic has changed to include fentanyl. According to the CDC, the rate of fentanyl overdoses in 2020 was 18 times higher than in 2013. Fentanyl currently accounts for the vast majority of all opioid overdoses and almost 70% of all drug overdose deaths. Its impact on overdose deaths and prevalence in street drugs other than opioids (i.e., stimulants) has led many in the field to refer to fentanyl as the Fourth Wave of the Opioid Epidemic. In this post we’ll unpack some basics on fentanyl, how it has changed the landscape for drug users, and how we can think about effective solutions to this new problem. While using fentanyl, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office).

Therapeutic Effects
Testing your drugs is the only foolproof way to be sure they are not laced with fentanyl, according to the CDC. Test strips are low-cost compared to other interventions, and they typically return results in five minutes or less. At Recovery Guide, our mission is to connect as many individuals struggling with mental health and substance abuse disorders to reputable treatment facilities. Substances can mask or enhance the effects of others making it harder to gauge how intoxicated you are. You can always take more of a substance, but you can’t take less. There are many things that can impact intoxication, overdose and bad reactions like feeling tired, being sick, or different emotional states.
Education about the risks of fentanyl use, increased access to naloxone, and comprehensive addiction treatment programs are crucial in addressing this crisis. If you or someone you know is struggling with fentanyl use, it is essential to seek professional help. Recovery is possible with the proper support and treatment. People taking a daily prescribed dose will become dependent on the drug and will have withdrawal symptoms if they stop it. This is not an addiction but instead a physiological response.
That’s precisely why sellers prefer the US Postal Service over FedEx or UPS. In a time of noise, confusion, and spin, we’re committed to clarity, truth, and depth — even when it’s hard. The National Institute on Drug Abuse supports research to develop new ways to treat OUD and to help people find treatments that are right for them. As these are unofficial terms, they can rapidly change and vary from region to region.
Fentanyl Is Potent And Dangerous, But Experts Say Many Myths About Exposure And Risk Do More Harm Than Good
If you test one pill from a bottle or bag of pills, that one dose might not have fentanyl in it, but the others might. Two important harm reduction tools are the medication naloxone (also known by its brand name Narcan) and fentanyl test strips. The kidneys of older adults may not work as well as they used to.
It is nearly impossible to tell if drugs have been mixed with fentanyl unless you test your drugs with fentanyl test strips. Illegal fentanyl, however, has an unknown amount of fentanyl and may be mixed with other drugs, which may result in harmful behaviors. In a medical setting, people take prescribed fentanyl for severe or chronic pain. Doctors will only prescribe the fentanyl patch to people who are already tolerant of opioid therapy that is similar in strength.